Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins

Author:

Pires Camilla Valente12ORCID,Oberstaller Jenna12,Wang Chengqi12,Casandra Debora12,Zhang Min12,Chawla Jyotsna123,Adapa Swamy Rakesh12,Otto Thomas D.4,Ferdig Michael T.5,Rayner Julian C.6,Jiang Rays H. Y.12,Adams John H.12ORCID

Affiliation:

1. Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA

2. USF Genomics Program, College of Public Health, University of South Florida, Tampa, Florida, USA

3. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States

4. Institute of Infection, Immunity and Inflammation, MVLS, University of Glasgow, Glasgow, United Kingdom

5. Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA

6. Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom

Abstract

Malaria control is seriously threatened by the emergence and spread of Plasmodium falciparum resistance to the leading antimalarial, artemisinin. The potent killing activity of artemisinin results from oxidative damage unleashed by free heme activation released by hemoglobin digestion.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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