In VivoEmergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli-Reference-Cited by-同舟云学术

In VivoEmergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli

Published:2012-05-29 Issue:8 Volume:56 Page:4516-4518
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Spanu Teresa,De Angelis Giulia,Cipriani Michela,Pedruzzi Barbara,D'Inzeo Tiziana,Cataldo Maria Adriana,Sganga Gabriele,Tacconelli Evelina

Abstract

ABSTRACTAlthough resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistancein vivo. We report two cases of patients with infections due to SHV-12-producingKlebsiella pneumoniaeandK. pneumoniaecarbapenemase-3 (KPC-3)-producingEscherichia coli, which developed tigecycline resistancein vivoafter treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference33 articles.

1. Application of minimal sequence quality values prevents misidentification of the blaSHV type in single bacterial isolates carrying different SHV extended-spectrum β-lactamase genes;Al Naiemi;J. Clin. Microbiol.,2006

2. Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient;Al-Qadheeb;Ann. Saudi Med.,2010

3. Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline;Anthony;Clin. Infect. Dis.,2008

4. Validation and reproducibility assessment of tigecycline MIC determinations by Etest;Bolmström;J. Clin. Microbiol.,2007

5. Safety and efficacy of tigecycline in treatment of skin and skin structure infections: results of a double-blind phase 3 comparison study with vancomycin-aztreonam;Breedt;Antimicrob. Agents Chemother.,2005

Cited by 58 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genomic features of in vitro selected mutants of Escherichia coli with decreased susceptibility to tigecycline;Journal of Global Antimicrobial Resistance;2022-12

2. Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline;PLOS Biology;2022-09-28

3. Characterization of Tigecycline Resistance Among Tigecycline Non-susceptible Klebsiella pneumoniae Isolates From Humans, Food-Producing Animals, and in vitro Selection Assay;Frontiers in Microbiology;2021-08-05

4. Risk Factors for Mortality in Patients with Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae and Escherichia coli bacteremia;Infection & Chemotherapy;2021

5. Safety and Efficacy of Tigecycline in Intensive Care Unit Patients Based on Therapeutic Drug Monitoring;Therapeutic Drug Monitoring;2020-12