<i>N</i> <sup>6</sup> -Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections-Reference-Cited by-同舟云学术

N ⁶ -Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Feng Jian¹²,Meng Wen¹²,Chen Luping¹²,Zhang Xinquan¹²,Markazi Ashley¹²,Yuan Weiming³,Huang Yufei¹⁴⁵⁶,Gao Shou-Jiang¹²^ORCID

Affiliation:

1. Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

4. Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

6. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Innate immunity is central to controlling pathogenic infections and maintaining the homeostasis of the host. In this study, we have revealed a novel mechanism regulating innate immune responses during viral and bacterial infections.

Funder

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03349-22

Reference39 articles.

1. Pathogen Recognition and Innate Immunity

2. Innate Immunity

3. Mitogen-activated protein kinases in innate immunity