MAP Kinases in the Immune Response

Author:

Dong Chen123,Davis Roger J.123,Flavell Richard A.123

Affiliation:

1. Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195-7650;

2. Howard Hughes Medical Institute and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachuetts 01605;

3. Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520;

Abstract

MAP kinases are among the most ancient signal transduction pathways and are widely used throughout evolution in many physiological processes. In mammalian species, MAP kinases are involved in all aspects of immune responses, from the initiation phase of innate immunity, to activation of adaptive immunity, and to cell death when immune function is complete. In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses.

Publisher

Annual Reviews

Subject

Immunology,Immunology and Allergy

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