DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation

Author:

Chen Yingshan12,Yao Yongxuan13,Zhao Kaitao4ORCID,Liu Canyu12,Yuan Yifei12,Sun Hao12,Huang Dan12,Zheng Yi5,Zhou Yuan1,Chen Jizheng1ORCID,Wang Yun1ORCID,Wu Chunchen6,Zhang Bixiang7,Guan Yujuan8,Li Feng8,Pei Rongjuan1,Chen Xinwen129ORCID

Affiliation:

1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou, China

4. State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China

5. School of Life Science, Northeast Forestry University, Harbin, China

6. Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

7. Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

8. Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China

9. Guangzhou Laboratory, Guangzhou, China

Abstract

The biogenesis and eradication of HBV cccDNA have been a research priority in recent years. In this study, we identified the DNA repair factor PARP1 as a host factor required for the HBV de novo cccDNA formation.

Funder

national basic research priorities program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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