Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx

Author:

Liu Canyu12,Zhao Kaitao3ORCID,Chen Yingshan12,Yao Yongxuan4,Tang Jielin15,Wang Jingjing3,Xu Chonghui12,Yang Qi15,Zheng Yi12,Yuan Yifei12,Sun Hao12,Zhang Yongli1,Zhou Yuan1,Chen Jizheng5,Wang Yun1ORCID,Wu Chunchen6,Pei Rongjuan1,Chen Xinwen157ORCID

Affiliation:

1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, China

2. University of Chinese Academy of Sciences, Beijing, China

3. State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China

4. Department of Gastroenterology, Guangzhou Women and Children’s Medical Center, Guangzhou, China

5. Guangzhou Laboratory, Guangzhou, China

6. Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

7. Guangzhou Medical University, Guangzhou, China

Abstract

The glycerol-3-phosphate (G3P) shuttle is important for the delivery of cytosolic reducing equivalents into mitochondria for oxidative phosphorylation. The study analyzed two key components of the G3P shuttle and identified GPD2 as a restriction factor in HBV replication.

Funder

MOST | National Key Research and Development Program of China

The Pearls River Talent Recruitment Program

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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