The Viral ORF3 Protein Is Required for Hepatitis E Virus Apical Release and Efficient Growth in Polarized Hepatocytes and Humanized Mice-Reference-Cited by-同舟云学术

The Viral ORF3 Protein Is Required for Hepatitis E Virus Apical Release and Efficient Growth in Polarized Hepatocytes and Humanized Mice

Published:2021-11-09 Issue:23 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sari Gulce¹^ORCID,Zhu Jingting²,Ambardekar Charuta²,Yin Xin²,Boonstra Andre¹,Feng Zongdi²³^ORCID,Vanwolleghem Thomas¹⁴⁵^ORCID

Affiliation:

1. Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands

2. Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

3. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

4. Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

5. Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium

Abstract

HEV infections are associated with significant morbidity and mortality. HEV gt3 additionally can cause persistent infection, which can rapidly progress to liver cirrhosis.

Funder

Foundation for Liver and Gastrointestinal Research

Fund for Scientific Research Flanders

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00585-21

Reference43 articles.

1. ICTV Virus Taxonomy Profile: Hepeviridae

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3. Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment

4. Clinical Manifestations, Pathogenesis and Treatment of Hepatitis E Virus Infections

5. Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis

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