The Viral ORF3 Protein Is Required for Hepatitis E Virus Apical Release and Efficient Growth in Polarized Hepatocytes and Humanized Mice

Author:

Sari Gulce1ORCID,Zhu Jingting2,Ambardekar Charuta2,Yin Xin2,Boonstra Andre1,Feng Zongdi23ORCID,Vanwolleghem Thomas145ORCID

Affiliation:

1. Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands

2. Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

3. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

4. Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

5. Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium

Abstract

HEV infections are associated with significant morbidity and mortality. HEV gt3 additionally can cause persistent infection, which can rapidly progress to liver cirrhosis.

Funder

Foundation for Liver and Gastrointestinal Research

Fund for Scientific Research Flanders

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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