Multiple Functions of Hepatitis E Virus ORF3-Reference-Cited by-同舟云学术

Multiple Functions of Hepatitis E Virus ORF3

Published:2024-07-11 Issue:7 Volume:12 Page:1405
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Jiao Fengyuan¹,Zhao Yu²,Zhou Gengxu¹,Meng Chi¹,Wang Lingjie¹,Wu Shengping¹,Li Jixiang¹,Cao Liting¹^ORCID,Zhou Bo³,Luo Yichen¹,Jiao Hanwei¹

Affiliation:

1. The College of Veterinary Medicine, Southwest University, Chongqing 402460, China

2. Ministry of Agriculture and Rural Affairs Key Laboratory of Crop Genitic Resources and Germplasm Innovation in Karst Region, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Science, Guiyang 550005, China

3. Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Yujinxiang Street 573, Changchun 130102, China

Abstract

Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.

Funder

the Natural Science Foundation of Chongqing

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-2607/12/7/1405/pdf

Reference50 articles.

1. Hepatitis E Virus Infection;Kamar;Nat. Rev. Dis. Primers,2017

2. Hepatitis E: An Emerging Infection in Developed Countries;Dalton;Lancet Infect. Dis.,2008

3. Hepatitis E Virus Cell Culture Models;Okamoto;Virus Res.,2011

4. The Viral ORF3 Protein Is Required for Hepatitis E Virus Apical Release and Efficient Growth in Polarized Hepatocytes and Humanized Mice;Sari;J. Virol.,2021

5. Osamudiamen, F.T., Akanbi, O.A., Zander, S., Oluwayelu, D.O., Bock, C.-T., and Klink, P. (2021). Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria. Viruses, 13.

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