A Same-Genus Screening Approach Reveals Novel Effectors and New Possibilities for Investigating Chlamydia Pathogenesis

Abstract

Chlamydiae are obligate intracellular pathogens that rely on secreted effector proteins to establish their intracellular niche. In this issue of the Journal of Bacteriology , Yanatori et al. describe a screen for Chlamydia pneumoniae effectors, performed in Chlamydia trachomatis , which identified several new proteins that are translocated during infection (I).