Unchaining mini Bacillus Strain PG10: Relief of FlgM-Mediated Repression of Autolysin Genes

Author:

van Tilburg Amanda Y.1,Fülleborn Julius A.1,Reder Alexander2,Völker Uwe2,Stülke Jörg3,van Heel Auke J.1,Kuipers Oscar P.1ORCID

Affiliation:

1. Department of Molecular Genetics, University of Groningen, Groningen, the Netherlands

2. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

3. Institute of Microbiology and Genetics, Georg-August University Göttingen, Göttingen, Germany

Abstract

Reduction of the size of bacterial genomes is relevant for understanding the minimal requirements for cellular life as well as from a biotechnological point of view. Although the genome-minimized Bacillus subtilis strain PG10 displays several beneficial traits as a microbial cell factory compared to its parental strain, a defect at the final stage of cell division was introduced during the genome reduction process.

Funder

European Commission

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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