Unchaining mini Bacillus Strain PG10: Relief of FlgM-Mediated Repression of Autolysin Genes-Reference-Cited by-同舟云学术

Unchaining mini Bacillus Strain PG10: Relief of FlgM-Mediated Repression of Autolysin Genes

Published:2021-08-26 Issue:18 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

van Tilburg Amanda Y.¹,Fülleborn Julius A.¹,Reder Alexander²,Völker Uwe²,Stülke Jörg³,van Heel Auke J.¹,Kuipers Oscar P.¹^ORCID

Affiliation:

1. Department of Molecular Genetics, University of Groningen, Groningen, the Netherlands

2. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

3. Institute of Microbiology and Genetics, Georg-August University Göttingen, Göttingen, Germany

Abstract

Reduction of the size of bacterial genomes is relevant for understanding the minimal requirements for cellular life as well as from a biotechnological point of view. Although the genome-minimized Bacillus subtilis strain PG10 displays several beneficial traits as a microbial cell factory compared to its parental strain, a defect at the final stage of cell division was introduced during the genome reduction process.

Funder

European Commission

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01123-21

Reference30 articles.

1. Large-scale reduction of the Bacillus subtilis genome: consequences for the transcriptional network, resource allocation, and metabolism

2. Genome Engineering Reveals Large Dispensable Regions in Bacillus subtilis

3. Less Is More: Toward a Genome-ReducedBacillusCell Factory for “Difficult Proteins”