Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

Author:

Muenchhoff M.1234ORCID,Chung A. W.5,Roider J.12467ORCID,Dugast Anne-Sophie8,Richardson Simone910,Kløverpris Henrik61112,Leslie Alasdair612,Ndung’u Thumbi26121314,Moore Penny910ORCID,Alter Galit14,Goulder Philip J. R.12

Affiliation:

1. Department of Paediatrics, University of Oxford, Oxford, United Kingdom

2. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

3. Max von Pettenkofer Institute, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany

4. German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany

5. Department of Immunology and Microbiology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia

6. Africa Health Research Institute (AHRI), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

7. Department of Infectious Diseases, Ludwig Maximilians University, Munich, Germany

8. Rubius Diagnostics, Cambridge, Massachusetts, USA

9. Centre for HIV and STI’s, National Institute for Communicable Diseases, Johannesburg, South Africa

10. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa

11. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

12. Department of Infection and Immunity, University College London, London, United Kingdom

13. Max Planck Institute for Infection Biology, Berlin, Germany

14. The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA

Abstract

To protect future generations against HIV, a vaccine will need to induce immunity by the time of sexual debut and hence requires immunization during childhood. Current strategies for a prophylactic HIV vaccine include the induction of a broadly neutralizing antibody response and the recruitment of potent effector functions of immune cells via the constant antibody Fc region.

Funder

amfAR, The Foundation for AIDS Research

Wellcome

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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