Defining Polysaccharide-Specific Antibody Targets against Vibrio cholerae O139 in Humans following O139 Cholera and following Vaccination with a Commercial Bivalent Oral Cholera Vaccine, and Evaluation of Conjugate Vaccines Targeting O139-Reference-Cited by-同舟云学术

Defining Polysaccharide-Specific Antibody Targets against Vibrio cholerae O139 in Humans following O139 Cholera and following Vaccination with a Commercial Bivalent Oral Cholera Vaccine, and Evaluation of Conjugate Vaccines Targeting O139

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Kamruzzaman Mohammad¹²^ORCID,Kelly Meagan¹,Charles Richelle C.¹³^ORCID,Harris Jason B.¹⁴⁵,Calderwood Stephen B.¹³,Akter Aklima¹²,Biswas Rajib¹²,Kaisar M. Hasanul²,Bhuiyan Taufiqur R.²^ORCID,Ivers Louise C.¹³⁶,Ternier Ralph⁷,Jerome Jean-Gregory⁷,Pfister Hélene B.⁸,Lu Xiaowei⁸,Soliman Sameh E.⁸,Ruttens Bart⁸,Saksena Rina⁸,Mečárová Jana⁹,Čížová Alžbeta⁹,Qadri Firdausi²,Bystrický Slavomír⁹,Kováč Pavol⁸,Xu Peng⁸,Ryan Edward T.¹³¹⁰

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

2. International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh

3. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

4. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

5. Division of Global Health, MassGeneral Hospital for Children, Boston, Massachusetts, USA

6. Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA

7. Partners In Health/Zanmi Lasante, Cange, Haiti

8. NIDDK, LBC, National Institutes of Health, Bethesda, Maryland, USA

9. Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic

10. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

Abstract

Cholera is a severe dehydrating illness of humans caused by Vibrio cholerae serogroup O1 or O139. Protection against cholera is serogroup specific, and serogroup specificity is defined by O-specific polysaccharide (OSP).

Funder

Bill and Melinda Gates Foundation

Intramural Research Program of the NIH and NIDDK

The Grant Agency of the Slovak Academy of Sciences VEGA

HHS | NIH | Fogarty International Center

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00114-21