miR-34c-3p Regulates Protein Kinase A Activity Independent of cAMP by Dicing <i>prkar2b</i> Transcripts in Theileria annulata-Infected Leukocytes-Reference-Cited by-同舟云学术

miR-34c-3p Regulates Protein Kinase A Activity Independent of cAMP by Dicing prkar2b Transcripts in Theileria annulata-Infected Leukocytes

Published:2023-04-20 Issue:2 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Haidar Malak¹²³,Tajeri Shahin²⁴,Momeux Laurence²,Mourier Tobias¹,Ben-Rached Fathia¹,Mfarrej Sara¹,Rchiad Zineb¹⁵,Pain Arnab¹⁶^ORCID,Langsley Gordon²

Affiliation:

1. Pathogen Genomics Laboratory, Bioscience Program, Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia

2. Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France

3. de Duve Institute, Université Catholique de Louvain, Brussels, Belgium

4. Institute of Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

5. Institute of Biological Sciences (ISSB), Faculty of Medical Sciences, Mohammed VI Polytechnic University (UM6P), Ben Guerir, Morocco

6. International Institute for Zoonosis Control, GI-CoRE, Hokkaido University, Sapporo, Japan

Abstract

Small microRNA levels are altered in many diseases, including those caused by parasites. Here, we describe how infection by two important animal and human parasites, Theileria annulata and Plasmodium falciparum , induce changes in infected host cell miR-34c-3p levels to regulate host cell PKA kinase activity by targeting mammalian prkar2b .

Funder

Agence Nationale de la

King Abdullah University of Science and Technology

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00526-22

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