Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?-Reference-Cited by-同舟云学术

Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

Published:2020-06-24 Issue:3 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Mamber Stephen W.¹,Krakowka Steven²,Osborn Jeffrey³,Saberski Lloyd⁴,Rhodes Ryan G.⁵,Dahlberg Albert E.⁶,Pond-Tor Sunthorn⁶,Fitzgerald Kara⁷,Wright Neal⁸,Beseme Sarah⁹,McMichael John¹⁹

Affiliation:

1. The Institute for Therapeutic Discovery, Delanson, New York, USA

2. The Ohio State University, Columbus, Ohio, USA

3. The University of Kentucky, Lexington, Kentucky, USA

4. Yale University, New Haven, Connecticut, USA

5. The University of North Carolina—Wilmington, Wilmington, North Carolina, USA

6. Brown University, Providence, Rhode Island, USA

7. Sandy Hook Clinic, Sandy Hook, Connecticut, USA

8. CMC Biosciences, Beverly, Massachusetts, USA

9. Beech Tree Labs, Providence, Rhode Island, USA

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines, including interleukin-1 (IL-1), IL-6, CCL2 protein, and CXCL10 protein. In the absence of proven antiviral agents or an effective vaccine, substances with immunomodulatory activity may be able to inhibit inflammatory and Th1 cytokines and/or yield an anti-inflammatory and/or Th2 immune response to counteract COVID-19 symptoms and severity.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00288-20

Reference29 articles.

1. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

2. An interferon-?-related cytokine storm in SARS patients

3. T Cell Responses to Whole SARS Coronavirus in Humans

4. Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4 + T Cells Are Important in Control of SARS-CoV Infection

5. T cell-mediated immune response to respiratory coronaviruses

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