Activation of the Extracytoplasmic Function σ Factor σ <sup>V</sup> in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV-Reference-Cited by-同舟云学术

Activation of the Extracytoplasmic Function σ Factor σ ^V in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV

Published:2022-04-27 Issue:2 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Pannullo Anthony G.¹,Ellermeier Craig D.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

2. Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA

Abstract

Clostridioides difficile is a major cause of hospital-acquired diarrhea and represents an urgent concern due to the prevalence of antibiotic resistance and the rate of recurrent infections. We previously showed that σ V and the regulon under its control were involved in lysozyme resistance.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00092-22

Reference54 articles.

1. Centers for Disease Control and Prevention (U.S.). 2019. Antibiotic resistance threats in the United States 2019. Centers for Disease Control and Prevention (U.S.). https://stacks.cdc.gov/view/cdc/82532. Retrieved 4 January 2022.

2. Kelly CP Pothoulakis C LaMont JT. 2010. Clostridium difficile colitis. Review-article. Massachusetts Medical Society. https://www.nejm.org/doi/10.1056/NEJM199401273300406. Retrieved 31 August 2021.

3. Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis

4. Clostridium difficile infection in Europe: a hospital-based survey

5. Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus Vancomycin

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of Clostridioides difficile mutants with increased daptomycin resistance;Journal of Bacteriology;2024-03-21

2. Identification of DraRS in Clostridioides difficile, a Two-Component Regulatory System That Responds to Lipid II-Interacting Antibiotics;Journal of Bacteriology;2023-10-26

3. The role of site-2-proteases in bacteria: a review on physiology, virulence, and therapeutic potential;microLife;2023

4. Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype;Journal of Bacteriology;2022-10-18