Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype-Reference-Cited by-同舟云学术

Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype

Published:2022-10-18 Issue:10 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Rouchon Candace N.¹²,Weinstein Arielle J.¹²,Hutchison Carissa A.¹²,Zubair-Nizami Zahra B.¹²,Kohler Petra L.³,Frank Kristi L.¹^ORCID

Affiliation:

1. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. Henry M. Jackson Foundation for Military Medicine, Rockville, Maryland, USA

3. University of Minnesota, Minneapolis, Minnesota, USA

Abstract

Enterococcus faecalis is a leading cause of health-care-associated infections for which there are limited treatment options. E. faecalis is resistant to several antibiotics and to high concentrations of the human antimicrobial enzyme lysozyme. The molecular mechanisms that mediate lysozyme resistance in E. faecalis are complex and remain incompletely characterized.

Funder

DOD | Uniformed Services University of the Health Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00247-22

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5. Enterococcus faecalis Constitutes an Unusual Bacterial Model in Lysozyme Resistance

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