Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages-Reference-Cited by-同舟云学术

Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages

Published:2018-04-25 Issue:2 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Boyce Kylie J.¹,De Souza David P.²,Dayalan Saravanan²,Pasricha Shivani¹,Tull Dedreia²,McConville Malcolm J.³,Andrianopoulos Alex¹

Affiliation:

1. School of Biosciences, The University of Melbourne, Melbourne, Australia

2. Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia

3. Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, Melbourne, Australia

Abstract

This study in a dimorphic fungal pathogen uncovered a role for a yeast-specific cytochrome P450 (CYP)-encoding gene in the ability of T. marneffei to grow as yeast cells within the host macrophages. This report will inspire further research into the role of CYPs and secondary metabolite synthesis during fungal pathogenic growth.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00056-18

Reference61 articles.

1. Natural products of filamentous fungi: enzymes, genes, and their regulation

2. The evolutionary history of Cytochrome P450 genes in four filamentous Ascomycetes

3. The CYPome (Cytochrome P450 complement) of Aspergillus nidulans

4. Identification ofHistoplasma capsulatumTranscripts Induced in Response to Reactive Nitrogen Species

5. Spectroscopic and kinetic studies of Nor1, a cytochrome P450 nitric oxide reductase from the fungal pathogen Histoplasma capsulatum

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Differential innate immune responses of human macrophages and bronchial epithelial cells against Talaromyces marneffei;mSphere;2023-10-24

2. An Overlooked and Underrated Endemic Mycosis—Talaromycosis and the Pathogenic Fungus Talaromyces marneffei;Clinical Microbiology Reviews;2023-03-23