Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases-Reference-Cited by-同舟云学术

Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
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language:en
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Author:

Alattraqchi Ahmed Ghazi¹,Mohd Rani Farahiyah¹,A. Rahman Nor Iza¹^ORCID,Ismail Salwani¹,Cleary David W.²³^ORCID,Clarke Stuart C.²³⁴⁵⁶^ORCID,Yeo Chew Chieng¹^ORCID

Affiliation:

1. Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia

2. Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

3. NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Trust, Southampton, United Kingdom

4. Global Health Research Institute, University of Southampton, Southampton, United Kingdom

5. School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia

6. Centre for Translational Research, IMU Institute for Research, Development and Innovation (IRDI), Kuala Lumpur, Malaysia

Abstract

Bacteria of the genus Acinetobacter are important hospital-acquired pathogens, with carbapenem-resistant A. baumannii listed by the World Health Organization as the one of the top priority pathogens. Whole-genome sequencing of carbapenem-resistant A. baumannii AC1633 and A. nosocomialis AC1530, which were isolated from the main tertiary hospital in Terengganu, Malaysia, led to the discovery of a large, ca. 170-kb plasmid that harbored genes encoding the New Delhi metallo-β-lactamase-1 (NDM-1) and OXA-58 carbapenemases alongside genes that conferred resistance to aminoglycosides, macrolides, and sulfonamides.

Funder

Ministry of Higher Education, Malaysia

Universiti Sultan Zainal Abidin

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01076-20

Reference91 articles.

1. Acinetobacter baumannii : Emergence of a Successful Pathogen

2. Acinetobacter baumannii: evolution of a global pathogen