Contact sites between host organelles and pathogens: boon or bane?-Reference-Cited by-同舟云学术

Contact sites between host organelles and pathogens: boon or bane?

Published:2023-12-20 Issue:6 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Mehra Chahat¹,Pernas Lena¹²³^ORCID

Affiliation:

1. Max Planck Institute for Biology of Ageing, Cologne, Germany

2. Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

3. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA

Abstract

ABSTRACT A microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite Toxoplasma gondii . We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and Toxoplasma .

Funder

EC | European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00448-23

Reference23 articles.

1. Coming together to define membrane contact sites

2. Pathogen vacuole membrane contact sites – close encounters of the fifth kind

3. An Electron Microscope Study of Toxoplasma

4. THE INTERACTION BETWEEN TOXOPLASMA GONDII AND MAMMALIAN CELLS

5. Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction