NanI Sialidase Enhances the Action of Clostridium perfringens Enterotoxin in the Presence of Mucus-Reference-Cited by-同舟云学术

NanI Sialidase Enhances the Action of Clostridium perfringens Enterotoxin in the Presence of Mucus

Published:2021-12-22 Issue:6 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Navarro Mauricio A.¹²,Li Jihong³,Beingesser Juliann¹,McClane Bruce A.³^ORCID,Uzal Francisco A.¹^ORCID

Affiliation:

1. California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, Davis, San Bernardino, California, USA

2. Instituto de Patología Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile

3. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Abstract

NanI is a sialidase produced by some Clostridium perfringens type F strains. Here, we found that NanI can significantly increase the action of C. perfringens enterotoxin (CPE), which is the main toxin responsible for severe human enteric disease caused by type F strains. This effect likely helps to explain why even some type F strains that produce small amounts of CPE are pathogenic.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00848-21

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