Dynamics of Different Classes and Subclasses of Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants after Coronavirus Disease 2019 and CoronaVac Vaccination in Thailand

Author:

Poolchanuan Prapassorn1,Matsee Wasin23,Sengyee Sineenart1,Siripoon Tanaya3,Dulsuk Adul1,Phunpang Rungnapa1,Pisutsan Phimphan23,Piyaphanee Watcharapong23,Luvira Viravarn3,Chantratita Narisara14ORCID

Affiliation:

1. Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Thai Travel Clinic, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

4. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

The antibody responses to new SARS-CoV-2 variants that occur in different populations remain unclear. In this study, we recruited 60 participants, including COVID-19 patients and CoronaVac-vaccinated individuals, in Thailand and determined the dynamic levels of the IgG, IgA, IgM, and IgG subclasses of antibodies against the spike protein (S) of four SARS-CoV-2 strains.

Funder

Mahidol University

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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