SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021-Reference-Cited by-同舟云学术

SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Alkhatib Mohammad¹,Svicher Valentina¹,Salpini Romina¹,Ambrosio Francesca Alessandra²,Bellocchi Maria Concetta¹,Carioti Luca¹,Piermatteo Lorenzo¹,Scutari Rossana¹,Costa Giosuè²³,Artese Anna²³,Alcaro Stefano²³,Shafer Robert⁴,Ceccherini-Silberstein Francesca¹^ORCID

Affiliation:

1. Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy

2. Dipartimento di Scienze della Salute, Campus S. Venuta, Università degli Studi “Magna Graecia” di Catanzaro, Catanzaro, Italy

3. Net4Science Academic Spin-Off, Campus S. Venuta, Università Magna Græcia di Catanzaro, Catanzaro, Italy

4. Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA

Abstract

Since the emergence of SARS-CoV-2, several recurrent mutations, particularly in the spike protein, arose during human-to-human transmission or spillover events between humans and animals, generating distinct worrisome variants of concern (VOCs) or of interest (VOIs), designated as such due to their clinical and diagnostic impacts. Characterizing these variants and their related mutations is important in tracking SAR-CoV-2 evolution and understanding the efficacy of vaccines and therapeutics based on monoclonal antibodies, convalescent-phase sera, and direct antivirals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01096-21

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