The Vancomycin Resistance-Associated Regulatory System VraSR Modulates Biofilm Formation of Staphylococcus epidermidis in an ica -Dependent Manner

Author:

Wu Youcong12,Meng Yuanyuan1,Qian Lian1,Ding Baixing2,Han Haiyan23,Chen Hongling1,Bai Li1,Qu Di2,Wu Yang2

Affiliation:

1. Department of Medical Microbiology and Immunology, School of Basic Medical Sciences, Dali University, Dali, Yunnan Province, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

3. Department of Laboratory Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

Abstract

S. epidermidis is a leading cause of hospital-acquired catheter-related infections, and its pathogenicity depends mostly on its ability to form biofilms on implants. The biofilm formation is a complex procedure that involves multiple regulating factors. Here, we show that a vancomycin resistance-associated two-component regulatory system, VraSR, plays an important role in modulating S. epidermidis biofilm formation and tolerance to stress.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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