The Vancomycin Resistance-Associated Regulatory System VraSR Modulates Biofilm Formation of Staphylococcus epidermidis in an ica -Dependent Manner-Reference-Cited by-同舟云学术

The Vancomycin Resistance-Associated Regulatory System VraSR Modulates Biofilm Formation of Staphylococcus epidermidis in an ica -Dependent Manner

Published:2021-10-27 Issue:5 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Wu Youcong¹²,Meng Yuanyuan¹,Qian Lian¹,Ding Baixing²,Han Haiyan²³,Chen Hongling¹,Bai Li¹,Qu Di²,Wu Yang²

Affiliation:

1. Department of Medical Microbiology and Immunology, School of Basic Medical Sciences, Dali University, Dali, Yunnan Province, China

2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

3. Department of Laboratory Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

Abstract

S. epidermidis is a leading cause of hospital-acquired catheter-related infections, and its pathogenicity depends mostly on its ability to form biofilms on implants. The biofilm formation is a complex procedure that involves multiple regulating factors. Here, we show that a vancomycin resistance-associated two-component regulatory system, VraSR, plays an important role in modulating S. epidermidis biofilm formation and tolerance to stress.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00641-21

Reference49 articles.

1. Significant Enrichment and Diversity of the Staphylococcal Arginine Catabolic Mobile Element ACME in Staphylococcus epidermidis Isolates From Subgingival Peri-implantitis Sites and Periodontal Pockets

2. Detection of Methicillin-Resistant Staphylococci Isolated from Food Producing Animals: A Public Health Implication

3. Current concepts in biofilm formation of Staphylococcus epidermidis