Combatting Antibiotic-Resistant <i>Staphylococcus aureus</i>: Discovery of TST1N-224, a Potent Inhibitor Targeting Response Regulator VraRC, through Pharmacophore-Based Screening and Molecular Characterizations-Reference-Cited by-同舟云学术

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Combatting Antibiotic-Resistant Staphylococcus aureus: Discovery of TST1N-224, a Potent Inhibitor Targeting Response Regulator VraRC, through Pharmacophore-Based Screening and Molecular Characterizations

Published:2024-07-30 Issue:15 Volume:64 Page:6132-6146
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Hsu Ying-Chu¹,Liu Ching-Hui²,Wu Yi-Chen²,Lai Shu-Jung³⁴,Lin Chi-Jan²,Tseng Tien-Sheng²^ORCID

Affiliation:

1. Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation ChiaYi Christian Hospital, Chiayi 600566, Taiwan

2. Institute of Molecular Biology, National Chung Hsing University, Taichung 40202, Taiwan

3. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan

4. Research Center for Cancer Biology, China Medical University, Taichung 404333, Taiwan

Funder

Ditmanson Medical Foundation Chia-Yi Christian Hospital

National Science and Technology Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01046

Reference59 articles.

1. Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

2. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

3. Emergence of methicillin resistance predates the clinical use of antibiotics

4. Waves of resistance: Staphylococcus aureus in the antibiotic era

5. Mechanisms of vancomycin resistance in Staphylococcus aureus

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