Loss of β-Ketoacyl Acyl Carrier Protein Synthase III Activity Restores Multidrug-Resistant Escherichia coli Sensitivity to Previously Ineffective Antibiotics-Reference-Cited by-同舟云学术

Loss of β-Ketoacyl Acyl Carrier Protein Synthase III Activity Restores Multidrug-Resistant Escherichia coli Sensitivity to Previously Ineffective Antibiotics

Published:2022-06-29 Issue:3 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Hong Yaoqin¹^ORCID,Qin Jilong¹^ORCID,Verderosa Anthony D.¹^ORCID,Hawas Sophia¹,Zhang Bing²^ORCID,Blaskovich Mark A. T.²^ORCID,Cronan John E.³⁴^ORCID,Totsika Makrina¹^ORCID

Affiliation:

1. Centre of Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia

2. Centre for Superbug Solutions, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

3. Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

4. Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Abstract

Gram-negative pathogens are a major concern for global public health due to increasing rates of antibiotic resistance and the lack of new drugs. A major contributing factor toward antibiotic resistance in Gram-negative bacteria is their formidable outer membrane, which acts as a permeability barrier preventing many biologically active antimicrobials from reaching the intracellular targets and thus limiting their efficacy.

Funder

Queensland University of Technology

Georgina Sweet Award

Department of Health | National Health and Medical Research Council

Ramaciotti Foundations

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00117-22

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