Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations-Reference-Cited by-同舟云学术

Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Fröhlich Christopher¹^ORCID,Gama João A.²^ORCID,Harms Klaus²^ORCID,Hirvonen Viivi H. A.³^ORCID,Lund Bjarte A.⁴^ORCID,van der Kamp Marc W.³^ORCID,Johnsen Pål J.²^ORCID,Samuelsen Ørjan²⁵^ORCID,Leiros Hanna-Kirsti S.¹^ORCID

Affiliation:

1. The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway

2. Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway

3. School of Biochemistry, University of Bristol, Bristol, United Kingdom

4. Hylleraas Centre for Quantum Molecular Sciences, Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway

5. Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway

Abstract

Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicrobial classes, the importance of β-lactams, the most commonly used antibiotics, is still poorly studied.

Funder

Norges Forskningsråd

Helse Nord RHF

Joint Programming Initiative on Antimicrobial Resistance

General Medical Council

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00108-21