Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in Leishmania-Reference-Cited by-同舟云学术

Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in Leishmania

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Jensen Bryan C.¹,Phan Isabelle Q.¹²,McDonald Jacquelyn R.¹,Sur Aakash¹³,Gillespie Mark A.⁴,Ranish Jeffrey A.⁴,Parsons Marilyn¹⁵⁶,Myler Peter J.¹²³⁵⁶^ORCID

Affiliation:

1. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

2. Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington, USA

3. Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA

4. Institute for Systems Biology, Seattle, Washington, USA

5. Department of Pediatrics, University of Washington, Seattle, Washington, USA

6. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

Leishmania parasites cause a variety of serious human diseases, with no effective vaccine and emerging resistance to current drug therapy. We have previously shown that a novel DNA base called J is critical for transcription termination at the ends of the polycistronic gene clusters that are a hallmark of Leishmania and related trypanosomatids.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01204-20

Reference69 articles.

1. Histone acetylations mark origins of polycistronic transcription in Leishmania major

2. Transcription of Leishmania major Friedlin Chromosome 1 Initiates in Both Directions within a Single Region

3. Transcription Initiation and Termination on Leishmania major Chromosome 3