Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis-Reference-Cited by-同舟云学术

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

Published:2022-04-27 Issue:2 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Bravo Ruiz Gustavo¹^ORCID,Tinti Michele¹^ORCID,Ridgway Melanie¹^ORCID,Horn David¹^ORCID

Affiliation:

1. The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

Abstract

VSG expression represents a key parasite virulence mechanism and an example of extreme biology. Posttranscriptional gene expression controls in trypanosomatids also continue to be the subject of substantial research interest.

Funder

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00069-22

Reference43 articles.

1. Antigenic variation in African trypanosomes

2. Many trypanosome messenger RNAs share a common 5′ terminal sequence

3. Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene

4. RNA Polymerase I Transcribes Procyclin Genes and Variant Surface Glycoprotein Gene Expression Sites in Trypanosoma brucei

5. Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

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