Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic-Reference-Cited by-同舟云学术

Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Derr T. Hans¹,James Melissa A.²,Kuny Chad V.³⁴⁵⁶,Patel Devanshi R.⁷⁵⁶,Kandel Prem P.⁸,Field Cassandra⁷⁵⁶,Beckman Matthew D.⁹,Hockett Kevin L.⁸⁵⁶^ORCID,Bates Mark A.¹⁰,Sutton Troy C.⁷⁵⁶^ORCID,Szpara Moriah L.³⁴⁵⁶^ORCID

Affiliation:

1. Environmental Health and Safety, Pennsylvania State University, University Park, Pennsylvania, USA

2. Animal Resource Program, Pennsylvania State University, University Park, Pennsylvania, USA

3. Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA

4. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA

5. Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, USA

6. Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, USA

7. Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA

8. Department of Plant Pathology and Environmental Microbiology, Pennsylvania State University, University Park, Pennsylvania, USA

9. Department of Statistics, Pennsylvania State University, University Park, Pennsylvania, USA

10. Occupational Medicine Program, Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

The COVID-19 pandemic led to unprecedented pressure on health care and research facilities to provide personal protective equipment. The respiratory nature of the SARS-CoV2 pathogen makes respirator facepieces a critical protective measure to limit inhalation of this virus.

Funder

Pennsylvania State University, Huck Institutes for the Life Sciences

PSU | Institutes of Energy and the Environment, Pennsylvania State University

Pennsylvania State University

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00303-22

Reference60 articles.

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2. Centers for Disease Control and Prevention (CDC) National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) Division of Healthcare Quality Promotion (DHQP). 2008. Sterilizing practices: guideline for disinfection and sterilization in healthcare facilities. https://www.cdc.gov/infectioncontrol/guidelines/disinfection/sterilization/sterilizing-practices.html.

3. 3M Personal Safety Division. 2020. Disinfection of filtering facepiece respirators. 3M Tech Bull 4.

4. Battelle Memorial Institute. 2016. Final report for the Bioquell hydrogen peroxide vapor (HPV) decontamination for reuse of N95 respirators. Prep contract – study number 3245 U.S. Food Drug Adm 46. https://www.fda.gov/media/136386/download.

5. Can N95 Respirators Be Reused after Disinfection? How Many Times?

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