Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans-Reference-Cited by-同舟云学术

Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Schlievert Patrick M.¹^ORCID,Roller Richard J.¹^ORCID,Kilgore Samuel H.¹,Villarreal Miguel²,Klingelhutz Aloysius J.¹,Leung Donald Y. M.³

Affiliation:

1. Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

2. Rho Federal Systems Division, Inc., Durham, North Carolina, USA

3. Division of Allergy/Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA

Abstract

Atopic dermatitis (eczema, AD) with concurrent herpes simplex virus infection (eczema herpeticum, ADEH) is a severe form of AD. We show that ADEH patients are colonized with Staphylococcus aureus that primarily produces the superantigen toxic shock syndrome toxin-1 (TSST-1); however, significantly but to a lesser extent the superantigens staphylococcal enterotoxins A, B, and C are also represented in ADEH.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00608-21

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