Staphylococcal and Streptococcal Superantigen Exotoxins-Reference-Cited by-同舟云学术

Staphylococcal and Streptococcal Superantigen Exotoxins

Published:2013-07 Issue:3 Volume:26 Page:422-447
ISSN:0893-8512
Container-title:Clinical Microbiology Reviews
language:en
Short-container-title:Clin Microbiol Rev

Author:

Spaulding Adam R.¹,Salgado-Pabón Wilmara¹,Kohler Petra L.²,Horswill Alexander R.¹,Leung Donald Y. M.³,Schlievert Patrick M.¹²

Affiliation:

1. Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

2. Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

3. Department of Pediatrics, National Jewish Health, Denver, Colorado, USA

Abstract

SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Link

https://journals.asm.org/doi/pdf/10.1128/CMR.00104-12

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