Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids-Reference-Cited by-同舟云学术

Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids

Published:2021-12-22 Issue:6 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Hayashi Tsuyoshi¹^ORCID,Murakami Kosuke¹,Hirano Junki¹,Fujii Yoshiki¹,Yamaoka Yoko¹,Ohashi Hirofumi¹²,Watashi Koichi¹²³,Estes Mary K.⁴^ORCID,Muramatsu Masamichi¹^ORCID

Affiliation:

1. Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Applied Biological Science, Tokyo University of Science, Chiba, Japan

3. Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan

4. Departments of Molecular Virology and Microbiology and of Medicine, Baylor College of Medicine, Houston, Texas, USA

Abstract

Although there is an urgent need to develop effective antiviral therapy directed against HuNoV infection, compound screening to identify anti-HuNoV drug candidates has not been reported so far. Using a human HIE culture system, our compound screening successfully identified dasabuvir as a novel anti-HuNoV inhibitor.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00623-21

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