Genetic Heterogeneity and Recombination in Human Type 2 Astroviruses

Author:

De Grazia S.1,Medici M. C.2,Pinto P.3,Moschidou P.3,Tummolo F.2,Calderaro A.2,Bonura F.1,Banyai K.4,Giammanco G. M.1,Martella V.3

Affiliation:

1. Dipartimento di Scienze per la Promozione della Salute G. D'Alessandro, Università di Palermo, Palermo, Italy

2. Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università di Parma, Parma, Italy

3. Dipartimento di Sanità Pubblica e Zootecnia, Università Aldo Moro di Bari, Valenzano, Italy

4. Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian, Academy of Sciences, Budapest, Hungary

Abstract

ABSTRACT Novel lineages of human astrovirus (HAstV) types 2, 2c, and 2d have been identified. Upon sequencing of the 3′ end of the genome, the type 2c and 2d HAstVs were found to be open reading frame 1b (ORF1b)-ORF2 recombinant, with ORF1b being derived from type 3 and type 1 HAstVs, respectively. An ORF2 interlineage recombinant strain, 2c/2b, was also identified.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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5. Surveillance of human astrovirus circulation in Italy 2002–2005: emergence of lineage 2c strains;De Grazia S;Clin. Microbiol. Infect.,2011

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