Antibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis

Author:

Persson Lena12,Johansson Christian12,Rydén Cecilia12

Affiliation:

1. Department of Medical Biochemistry and Microbiology, Uppsala University BMC, Box 582, SE-75123 Uppsala, Sweden

2. Department of Infectious Diseases, Uppsala Academic Hospital, SE-75185 Uppsala, Sweden

Abstract

ABSTRACT Discrimination of soft tissue infection from osteomyelitis in diabetic foot infections is a common clinical problem. Staphylococcus aureus isolates from patients with osteomyelitis express bone sialoprotein-binding protein (Bbp) that binds the bone matrix protein bone sialoprotein. The serological assay with Bbp discriminated cases of osteomyelitis from soft tissue infections in patients with diabetic foot ulcers.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

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