In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein-Reference-Cited by-同舟云学术

In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein

Published:2013-08 Issue:8 Volume:20 Page:1333-1337
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Bodewes Rogier¹,Geelhoed-Mieras Martina M.¹,Wrammert Jens²³⁴,Ahmed Rafi²³,Wilson Patrick C.⁵,Fouchier Ron A. M.¹,Osterhaus Albert D. M. E.¹⁶,Rimmelzwaan Guus F.¹⁶

Affiliation:

1. Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands

2. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

3. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

4. Department of Pediatric Infectious Diseases, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia, USA

5. Department of Medicine/Rheumatology, University of Chicago, Chicago, Illinois, USA

6. Viroclinics Biosciences, Rotterdam, the Netherlands

Abstract

ABSTRACT Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro . This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8 + T cells by dendritic cells.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00339-13

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