FosB, a Cysteine-Dependent Fosfomycin Resistance Protein under the Control of ς W , an Extracytoplasmic-Function ς Factor in Bacillus subtilis-Reference-Cited by-同舟云学术

FosB, a Cysteine-Dependent Fosfomycin Resistance Protein under the Control of ς W , an Extracytoplasmic-Function ς Factor in Bacillus subtilis

Published:2001-04 Issue:7 Volume:183 Page:2380-2383
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Cao Min¹,Bernat Bryan A.²,Wang Zhepeng²,Armstrong Richard N.²,Helmann John D.¹

Affiliation:

1. Department of Microbiology, Cornell University, Ithaca, New York 14853-8101,1 and

2. Department of Biochemistry and the Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-01462

Abstract

ABSTRACT We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires ς W , and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn 2+ -dependent glutathione transferases but with a preference for Mg 2+ and l -cysteine as cofactors.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.183.7.2380-2383.2001

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