Glomerular Function and Urinary Biomarker Changes between Vancomycin and Vancomycin plus Piperacillin-Tazobactam in a Translational Rat Model-Reference-Cited by-同舟云学术

Glomerular Function and Urinary Biomarker Changes between Vancomycin and Vancomycin plus Piperacillin-Tazobactam in a Translational Rat Model

Published:2022-03-15 Issue:3 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chang Jack¹²³,Pais Gwendolyn M.¹²^ORCID,Valdez Kimberly¹,Marianski Sylwia¹,Barreto Erin F.⁴^ORCID,Scheetz Marc H.¹²³⁵^ORCID

Affiliation:

1. Midwestern University College of Pharmacy, Department of Pharmacy Practice, Downers Grove, Illinois, USA

2. Midwestern University College of Pharmacy, Center of Pharmacometric Excellence, Downers Grove, Illinois, USA

3. Northwestern Memorial Hospital, Department of Pharmacy, Chicago, Illinois, USA

4. Mayo Clinic, Department of Pharmacy, Rochester, Minnesota, USA

5. Midwestern University College of Graduate Studies, Department of Pharmacology, Downers Grove, Illinois, USA

Abstract

Clinical studies have reported additive nephrotoxicity associated with the combination of vancomycin (VAN) and piperacillin-tazobactam (TZP). This study assessed differences in glomerular filtration rate (GFR) and urinary biomarkers between rats receiving VAN and those receiving VAN + TZP.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02132-21

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