Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models

Abstract

Abstract In this study, the dynamic changes in the real-time glomerular filtration rate in acute kidney injury models were monitored via percutaneous glomerular filtration rate monitoring technology. Male C57BL/6 mice were used to establish sepsis, ischemia‒reperfusion, cisplatin, and antibiotic-induced acute kidney injury models. In addition to the real-time glomerular filtration rate, renal tissue NGAL and Kim-1 mRNA expression levels and serum creatinine and blood urea nitrogen levels were also used to evaluate renal function. The results showed that the changes in biomarkers always lagged the real-time glomerular filtration rate during the progression and recovery of renal injury. In sepsis-induced acute kidney injury, the glomerular filtration rate decreases significantly as early as 2 hours after modeling, similar to renal injury induced by ischemia‒reperfusion, and the glomerular filtration rate can still better reflect renal insufficiency in the recovery stage of injury. In a model of antibiotic-induced kidney injury, vancomycin plus piperacillin-tazobactam did not worsen nephrotoxicity.