Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort

Author:

Syed Rehan R.1ORCID,Catanzaro Donald G.2ORCID,Colman Rebecca E.1ORCID,Cooney Christopher G.3,Linger Yvonne3,Kukhtin Alexander V.3,Holmberg Rebecca C.3,Norville Ryan3,Crudu Valeriu4,Ciobanu Nelly4,Codreanu Alexandru4,Seifert Marva1ORCID,Hillery Naomi5,Chiles Peter1,Catanzaro Antonino1,Rodwell Timothy C.1

Affiliation:

1. Department of Medicine, University of California, San Diego, La Jolla, California, USA

2. Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA

3. Akonni Biosystems, Inc., Frederick, Maryland, USA

4. Phthisiopneumology Institute, Chișinău, Republic of Moldova

5. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA

Abstract

While the goal of universal drug susceptibility testing has been a key component of the WHO End TB Strategy, in practice, this remains inaccessible to many. Rapid molecular tests for tuberculosis (TB) and antituberculosis drug resistance could significantly improve access to testing.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference35 articles.

1. World Health Organization. 2022. Global tuberculosis report 2022. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2015. The End TB Strategy. World Health Organization, Geneva, Switzerland.

3. World Health Organization. 2021. WHO operational handbook on tuberculosis. Module 3: diagnosis—rapid diagnostics for tuberculosis detection, 2021 update. World Health Organization, Geneva, Switzerland.

4. World Health Organization. 2021. WHO announces updated definitions of extensively drug-resistant tuberculosis. World Health Organization, Geneva, Switzerland.

5. World Health Organization. 2021. Fact sheet: tuberculosis. World Health Organization, Geneva, Switzerland. https://www.who.int/news-room/fact-sheets/detail/tuberculosis.

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