Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium-Reference-Cited by-同舟云学术

Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Isnard Christophe¹²³,Hernandez Sara B.⁴,Guérin François¹²³,Joalland Fanny¹,Goux Didier⁵,Gravey François³^ORCID,Auzou Michel²,Enot David⁶⁷,Meignen Pierrick⁸,Giard Jean-Christophe¹,Cava Felipe⁴^ORCID,Cattoir Vincent⁹¹⁰¹¹^ORCID

Affiliation:

1. Normandie Univ, UNICAEN, EA4655 U2RM (équipe Antibio-résistance), Caen, France

2. Normandie Univ, UNICAEN, CHU de Caen, Service de Microbiologie, Caen, France

3. Normandie Univ, UNICAEN/UNIROUEN, EA2656 GRAM 2.0, Caen, France

4. Umeå University, MIMS—Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå, Sweden

5. Normandie Univ, UNICAEN, CMAbio, IBFA SF 4206 ICORE, Caen, France

6. Institut de Cancérologie, Institut Gustave Roussy, Villejuif, France

7. Metabolomics Platform, Institut Gustave Roussy, Villejuif, France

8. Normandie Univ, UNICAEN, IUT (département “STID”), Lisieux, France

9. Unité Inserm U1230, Université de Rennes 1, Rennes, France

10. CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France

11. CNR de la Résistance aux Antibiotiques (laboratoire associé ‘Entérocoques’), Rennes, France

Abstract

Enterococcus faecium has become a major opportunistic pathogen with the emergence of vancomycin-resistant enterococci (VRE). As part of the gut microbiota, they have to cope with numerous stresses, including effects of antibiotics and other xenobiotics, especially in patients hospitalized in intensive care units (ICUs) who receive many medications. The aim of this study was to investigate the impact of the most frequently prescribed xenobiotics for ICU patients on fitness, pathogenicity, and antimicrobial resistance of the vanB -positive E. faecium Aus0004 reference strain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01261-20

Reference48 articles.

1. International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

2. Drug Utilization Pattern in the Intensive Care Unit of a Tertiary Care Hospital

3. An exploratory analysis of medication utilization in a medical intensive care unit

4. Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection

5. Subinhibitory Concentrations of Ciprofloxacin Enhance Antimicrobial Resistance and Pathogenicity of Enterococcus faecium

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