Enhanced Post-Stationary-Phase Survival of a Clinical Thymidine-Dependent Small-Colony Variant of Staphylococcus aureus Results from Lack of a Functional Tricarboxylic Acid Cycle-Reference-Cited by-同舟云学术

Enhanced Post-Stationary-Phase Survival of a Clinical Thymidine-Dependent Small-Colony Variant of Staphylococcus aureus Results from Lack of a Functional Tricarboxylic Acid Cycle

Published:2007-04 Issue:7 Volume:189 Page:2936-2940
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Chatterjee Indranil¹,Herrmann Mathias¹,Proctor Richard A.²,Peters Georg³,Kahl Barbara C.³

Affiliation:

1. Institute of Medical Microbiology and Hygiene, Institutes of Infectious Disease Medicine, University of Saarland, Homburg/Saar, Germany

2. Departments of Medicine and of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin

3. Institute of Medical Microbiology, University Hospital of Münster, Münster, Germany

Abstract

ABSTRACT The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB , clpC , and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01444-06

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