A Member of an Ancient Family of Bacterial Amino Acids Transporters Contributes to Chlamydia Nutritional Virulence and Immune Evasion

Abstract

Many obligate intracellular bacteria, including members of the genus Chlamydia , cannot synthesize a variety of amino acids de novo and acquire these from host cells via largely unknown mechanisms. Previously, we determined that a missense mutation in ctl0225 , a conserved Chlamydia open reading frame of unknown function, mediated sensitivity to interferon gamma.