Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis-Reference-Cited by-同舟云学术

Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis

Published:1998-10-23 Issue:5389 Volume:282 Page:754-759
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Stephens Richard S.¹,Kalman Sue¹,Lammel Claudia¹,Fan Jun¹,Marathe Rekha¹,Aravind L.¹,Mitchell Wayne¹,Olinger Lynn¹,Tatusov Roman L.¹,Zhao Qixun¹,Koonin Eugene V.¹,Davis Ronald W.¹

Affiliation:

1. R. S. Stephens, C. Lammel, W. Mitchell are with the Program in Infectious Diseases, University of California, Berkeley, CA 94720, USA, and the Francis I. Proctor Foundation, University of California, San Francisco, CA 94143, USA. S. Kalman, J. Fan, R. Marathe, R. W. Davis are at the DNA Sequencing and Technology Center, Stanford University, Stanford, CA 94305, USA. L. Aravind, R. L. Tatusov, E. V. Koonin are at the National Center for Biotechnology Information, National Library of Medicine, National...

Abstract

Analysis of the 1,042,519–base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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