Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV-Reference-Cited by-同舟云学术

Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV

Published:2020-11-09 Issue:23 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lokugamage Kumari G.¹,Hage Adam¹,de Vries Maren²,Valero-Jimenez Ana M.²,Schindewolf Craig¹,Dittmann Meike²,Rajsbaum Ricardo¹³,Menachery Vineet D.¹³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

2. Department of Microbiology, New York University School of Medicine, New York, New York, USA

3. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

With the ongoing outbreak of COVID-19, differences between SARS-CoV-2 and the original SARS-CoV could be leveraged to inform disease progression and eventual treatment options. In addition, these findings could have key implications for animal model development as well as further research into how SARS-CoV-2 modulates the type I IFN response early during infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01410-20

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