STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity <i>In Vitro</i> with Limited Antiviral Efficacy <i>In Vivo</i>-Reference-Cited by-同舟云学术

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STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity In Vitro with Limited Antiviral Efficacy In Vivo

Published:2024-08-29 Issue:9 Volume:10 Page:3392-3407
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Broeckel Rebecca¹^ORCID,Browne Amanda¹,Sucoloski Scott¹,Cantizani Juan²,Simpson Juliet. K.³,Pesiridis Scott⁴,Ramanjulu Joshi M.⁴^ORCID,Stokes Neil⁵,Luthra Priya¹

Affiliation:

1. Infectious Diseases Research Unit, GSK R&D, Collegeville, Pennsylvania 19426, United States

2. Global Health Medicines R&D, GSK R&D, Tres Cantos, Madrid 28760, Spain

3. Target Discovery Research Projects, GSK R&D, Stevenage SG1 2NY, United Kingdom

4. Immunology Research Unit, GSK R&D, Collegeville, Pennsylvania 19426, United States

5. Infectious Diseases Research Unit, GSK R&D, Stevenage SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.4c00504

Reference41 articles.

1. Paving new roads toward the advancement of broad‐spectrum antiviral agents

2. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

3. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

4. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

5. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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