Toxoplasma gondii-Induced Neutrophil Extracellular Traps Amplify the Innate and Adaptive Response

Author:

Miranda Farlen J. B.1,Rocha Bruno C.1,Pereira Milton C. A.12ORCID,Pereira Larissa M. N.13,de Souza Erikson H. M.1,Marino Ana P.1,Costa Pedro A. C.1,Vasconcelos-Santos Daniel V.4,Antonelli Lis R. V.1,Gazzinelli Ricardo T.123ORCID

Affiliation:

1. Instituto Rene Rachou, FIOCRUZ-MG, Belo Horizonte, Minas Gerais, Brazil

2. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

4. Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Abstract

Approximately one-third of the human population is estimated to be chronically infected with the obligate intracellular parasite Toxoplasma gondii . Humans are accidental hosts that are infected with T. gondii after consumption of undercooked meat or contaminated water.

Funder

INCT-Vacinas

NIH/MCTIC-CNPq/MS-SCTIE-DECIT-SVS-DST-AIDS

FAPEMIG Universal

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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