A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei-Reference-Cited by-同舟云学术

A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Eisenhuth Nicole¹,Vellmer Tim¹,Rauh Elisa T.¹,Butter Falk²,Janzen Christian J.¹^ORCID

Affiliation:

1. Department of Cell & Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany

2. Quantitative Proteomics, Institute of Molecular Biology (IMB), Mainz, Germany

Abstract

Trypanosoma brucei is a unicellular parasite that causes devastating diseases like sleeping sickness in humans and the “nagana” disease in cattle in Africa. Fundamental to the establishment and prolongation of a trypanosome infection is the parasite's ability to escape the mammalian host's immune system by antigenic variation, which relies on periodic changes of a protein surface coat.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01352-21

Reference110 articles.

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