Streptococcus gordonii Poised for Glycan Feeding through a MUC5B-Discriminating, Lipoteichoic Acid-Mediated Outside-In Signaling Circuit-Reference-Cited by-同舟云学术

Streptococcus gordonii Poised for Glycan Feeding through a MUC5B-Discriminating, Lipoteichoic Acid-Mediated Outside-In Signaling Circuit

Published:2022-06-21 Issue:6 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Lima Bruno P.¹^ORCID,Davies Julia R.²,Wickström Claes²,Johnstone Karen F.¹,Hall Jeffrey W.¹,Svensater Gunnel²,Herzberg Mark C.¹^ORCID

Affiliation:

1. Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA

2. Section for Oral Biology and Pathology, Faculty of Odontology, Malmö University, Malmö, Sweden

Abstract

All organisms throughout the tree of life sense and respond to their surface environments. To discriminate among mucosal surface environmental cues, we report that Streptococcus gordonii recognizes a high-molecular-weight mucin glycoprotein, MUC5B, using the paired adhesins SspAB and lipoteichoic acid; the latter bridges the outside signal to an intramembrane two-component system to transcriptionally regulate a MUC5B-specific adhesin and genes that may facilitate glycan catabolism.

Funder

The Swedish Research Council

Office of the Vice President for Research University of Minnesota

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00118-22

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