Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to β-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model-Reference-Cited by-同舟云学术

Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to β-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rose Warren E.¹,Bienvenida Ana M.²,Xiong Yan Q.³⁴,Chambers Henry F.⁵,Bayer Arnold S.³⁴,Ersoy Selvi C.³

Affiliation:

1. School of Pharmacy, University of Wisconsin—Madison, Madison, Wisconsin, USA

2. Department of Pharmacy, UW Health, Madison, Wisconsin, USA

3. The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA

4. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

5. University of California at San Francisco School of Medicine, San Francisco, California, USA

Abstract

Supplementation of standard growth media (cation-adjusted Mueller-Hinton Broth [CAMHB]) with bicarbonate (NaHCO 3 ) increases β-lactam susceptibility of selected methicillin-resistant Staphylococcus aureus (MRSA) strains (“NaHCO 3 responsive”). This “sensitization” phenomenon translated to enhanced β-lactam efficacy in a rabbit model of endocarditis.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02072-19

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