Ceftaroline Resistance by Clone-Specific Polymorphism in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Ceftaroline Resistance by Clone-Specific Polymorphism in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lee Hyukmin¹,Yoon Eun-Jeong¹,Kim Dokyun¹,Kim Jung Wook²,Lee Kwang-Jun²,Kim Hyun Soo³,Kim Young Ree⁴,Shin Jong Hee⁵,Shin Jeong Hwan⁶,Shin Kyeong Seob⁷,Kim Young Ah⁸,Uh Young⁹,Jeong Seok Hoon¹

Affiliation:

1. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea

2. Division of Antimicrobial Resistance, National Institute of Health, Centers for Disease Control and Prevention, Cheongju, South Korea

3. Department of Laboratory Medicine, Hallym University College of Medicine, Hwaseong, South Korea

4. Department of Laboratory Medicine, School of Medicine, Jeju National University, Jeju, South Korea

5. Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South Korea

6. Department of Laboratory Medicine and Paik Institute for Clinical Research, Inje University College of Medicine, Busan, South Korea

7. Department of Laboratory Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea

8. Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South Korea

9. Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea

Abstract

A total of 281 nonduplicated Staphylococcus aureus blood isolates were collected from January to May 2017 from eight hospitals in South Korea to investigate the epidemiological traits of ceftaroline resistance in methicillin-resistant S. aureus (MRSA). Cefoxitin-disk diffusion tests and the mecA gene PCR revealed that 56.6% (159/281) of the S. aureus isolates were MRSA, and most belonged to ST5 (50.3%, 80/281) and ST72 (41.5%, 66/281).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00485-18

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